is it safe (for mom and baby) to take prednisone during pregnancy to increase platelette levels? | Mom Answers There are no controlled data in human pregnancy. Prednisone is only recommended for use during pregnancy when there are no alternatives and benefit outweighs risk. Can I Take Prednisone when I am Pregnant?. Taking prednisone while pregnant may create an increased risk of having a low birthweight baby, or having a stillbirth. Can You Take Prednisone While Pregnant? The Risks of Taking Prednisone During Pregnancy Appear to Be Very Low Share Pin Email It may not be safe to take the steroid drug prednisone during pregnancy. Researchers haven't studied this drug adequately in pregnant women, so it should be used. Is it safe to take prednisone while pregnant? Read on to learn more about prednisone and pregnancy. Taking prednisone during pregnancy. Taking Prednisone During Third Trimester. An_220302 posted: Hello! I was hoping to get some opinions on taking prednisone during pregnancy. I am 8 months. My mom has had to take prednisone for the last 26 years and began taking it when she was diagnosed with Ulcerative Colitis while also pregnant with me. Prednisone/Prednisolone and Pregnancy In every pregnancy, a woman starts out with a 3-5% chance of having a baby with a birth defect. This is called her Using this medicine while you are pregnant can harm your. Prednisone may lower your body's resistance and the vaccine may not work as well or you might get the.